A man's heart after 40: what really protects it
Heart and blood vessel disease is the leading cause of death in men. It sounds frightening, but there's good news in it: the risk is driven by a few things you can largely control. Not supplements and not your watch's readings, but a handful of "boring" levers.
What matters most
Nine factors you can influence account for more than 90% of the risk of a first heart attack: blood pressure, smoking, cholesterol, diabetes and belly fat, inactivity, diet, alcohol, stress. The gap between these levers and trendy "optimisations" is huge.
The levers — by strength
Fitness. The most underrated lever. Even a small improvement in stamina noticeably lowers mortality — comparable to quitting smoking. The biggest jump comes when you go from "barely moving" to "moderately fit". A guide: 150 minutes of aerobic exercise a week and two strength sessions.
Don't smoke. The fastest lever. Even one cigarette a day carries about half the excess risk of a pack — "cutting down" doesn't work, only quitting does. A year after quitting, the risk of heart disease halves. E-cigarettes are probably less harmful, but not harmless.
Blood pressure. The single biggest risk factor. Measure it at home with a validated upper-arm cuff.
A Mediterranean style. Proven in large trials: about 30% fewer heart events. Olive oil as the main fat, a handful of nuts a day, legumes, fish, vegetables. Salt — under 5 g a day, less ultra-processed food.
Fish, not fish oil. Oily fish twice a week is good for you. Over-the-counter omega-3 capsules haven't shown a benefit for the heart, and high doses raise the risk of rhythm problems.
Belly and sleep. Fat around the waist and sleep apnea raise blood pressure and the risk of rhythm problems.
Alcohol. "A glass of wine is good for the heart" — it didn't hold up. Don't start for your heart's sake, and if you drink — drink less.
Know your numbers
What your watch can't see, you find out from a doctor: blood pressure, cholesterol and, if possible, ApoB, Lp(a) — once in a lifetime (it's inherited and raised in about one in five people), blood sugar. At intermediate risk, a doctor may suggest a coronary artery calcium scan.
What about watches and rings?
An irregular rhythm notification is the most useful thing a watch can do: it's worth showing a doctor. But no notification doesn't rule out rhythm problems. Wrist blood pressure hasn't been validated yet — re-measure with an upper-arm cuff. And most importantly: a "perfect" dashboard can't see plaque in your arteries.
"Heart" supplements
No supplement has been shown to reduce heart attacks. In a head-to-head comparison, popular supplements didn't lower cholesterol, while a low dose of a statin lowered it noticeably. Red yeast rice is essentially a statin with no dose control and possible contaminants. Niacin showed no benefit in large trials, but there was harm. "Artery cleansing" and "dissolving plaque" have no data in humans.
About statins — honestly
We don't prescribe them. They're among the most studied medicines. Most "side effects" in blinded studies happened just as often on placebo. The decision is made with a doctor based on your personal risk. Fear and stopping them on your own raise the risk of heart attack and stroke.
When it's urgent
- Pressing, squeezing or burning pain behind the breastbone, especially on exertion, spreading to the arm, jaw or neck, with breathlessness, sweating or nausea — at rest, this is a reason to call an ambulance.
- Fainting during exertion.
- New or worsening breathlessness.
- Calf pain when walking that goes away at rest.
- New erection problems — also a reason to get your heart checked.
What to try this week
- Three brisk 30-minute walks.
- Measure your blood pressure at home morning and evening, two or three days in a row.
- Two portions of oily fish this week.
What this is based on
This article is based on topics from the VIA-L knowledge base. These are the published studies behind them:
- What to Know About the New Lipid Guidelines — JAMA, 2026 doi
- Traditional and Emerging Lipid Markers for Cardiovascular Risk Assessment in Young vs Older Adults — JAMA Network Open, 2026 doi
- Would you like to explore the 2026 ACC/AHA guideline recommendations for specific LDL-C and ApoB treatment targets across different risk categories, including the evidence for very aggressive LDL-C lowering (2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines — Journal of the American College of Cardiology, 2026 doi
- 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines — 2026 doi
- 2026 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association — 2026 doi
- Erectile Dysfunction as an Early Biomarker of Cardiovascular Toxicity: Mechanisms and Clinical Implications — Microvascular Research, 2026 doi
- Associations Between Erectile Dysfunction, Low Testosterone, and Cardiometabolic Risk: An Age Stratified, Propensity-Matched Cohort Study — International Journal of Impotence Research, 2026 doi
- Erectile dysfunction and cardiovascular health — Urology, 2026 doi
- Efficacy of Lifestyle Interventions in Treating Erectile Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials — The Journal of Sexual Medicine, 2026 doi
- Low-Intensity Shockwave Therapy for Erectile Dysfunction: An Abridged Cochrane Review — BJU International, 2026 doi
- Impact of an Interdisciplinary Weight Loss and Lifestyle Intervention on Testosterone and Scores for Sexual Activity on the FOSQ in Men With Obesity and Obstructive Sleep Apnea: Secondary Analyses of Data From the INTERAPNEA Randomized Trial — Maturitas, 2026 doi
- Comparative Effectiveness and Safety of Novel Antidiabetic Agents in the Management of Obstructive Sleep Apnea: A Systematic Review, Meta-Analysis, and Network Meta-Analysis — Respiratory Medicine, 2026 doi
Show all (121)
- Glucagon-Like Receptor Agonists and Next-Generation Incretin-Based Medications: Metabolic, Cardiovascular, and Renal Benefits — Lancet (London, England), 2026 doi
- Nutritional Modulators of Sleep: A Narrative Review of Vitamins, Minerals, Amino Acids, and Their Neurobiological and Chronoepigenetic Mechanisms — Chronobiology International, 2026 doi
- Impact of GLP-1 and Dual Agonists on the Incidence Of new Cases of Physician-Reported Sleep Apnea: A Real-World Study — Annals of the American Thoracic Society, 2026 doi
- Dietary Protocols to Promote and Improve Restful Sleep: A Narrative Review — Nutrition Reviews, 2026 doi
- The Role of Obstructive Sleep Apnea and CPAP Therapy in the Functional Hypogonadism of Male Patients With Severe Obesity — The Journal of Clinical Endocrinology and Metabolism, 2026 doi
- What Is a Cardiac CT Calcium Score? — JAMA, 2025 doi
- Effect of Lipid-Lowering Therapies on Lipoprotein(a) Levels: A Comprehensive Meta-Analysis of Randomized Controlled Trials — Atherosclerosis, 2025 doi
- Alcohol Use and Cardiovascular Disease: A Scientific Statement From the American Heart Association — Circulation, 2025 doi
- Low-Intensity Shockwave Therapy for Erectile Dysfunction — The Cochrane Database of Systematic Reviews, 2025 doi
- Associations Between Phosphodiesterase Type 5 Inhibitors and Vascular Function: A Systematic Review and Meta-Analysis on Randomized-Controlled Trials — Systematic Reviews, 2025 doi
- Diagnosis and Treatment of Obstructive Sleep Apnea — JAMA Internal Medicine, 2025 doi
- Unraveling the Connection Between the Mediterranean Diet and Sleep Health: From Biological Mechanisms to Clinical Implications — Sleep & Breathing = Schlaf & Atmung, 2025 doi
- Magnesium Is a Key Trace Element in Obstructive Sleep Apnea: Evidence From Mendelian Randomization Analysis and NHANES Database — Respiratory Medicine, 2025 doi
- The Effects of L-Theanine Consumption on Sleep Outcomes: A Systematic Review and Meta-Analysis — Sleep Medicine Reviews, 2025 doi
- Efficacy of Incretin-Based Therapies in Obesity-Related Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials — Sleep Medicine Reviews, 2025 doi
- Examining the Effect of L-Theanine on Sleep: A Systematic Review of Dietary Supplementation Trials — Nutritional Neuroscience, 2025 doi
- The Effect of Mediterranean Diet and Chrononutrition on Sleep Quality: A Scoping Review — Nutrition Journal, 2025 doi
- 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association — 2024 doi
- Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men : Individual Participant Data Meta-Analyses — Annals of Internal Medicine, 2024 doi
- Testosterone Replacement in Men With Sexual Dysfunction — The Cochrane Database of Systematic Reviews, 2024 doi
- The Princeton IV Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease — Mayo Clinic Proceedings, 2024 doi
- Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men With Hypogonadism — The Journal of Clinical Endocrinology and Metabolism, 2024 doi
- Treatment of OSA and Its Impact on Cardiovascular Disease, Part 2: JACC State-of-the-Art Review — Journal of the American College of Cardiology, 2024 doi
- Sleep Disorders — NEJM Evidence, 2024 doi
- Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity — The New England Journal of Medicine, 2024 doi
- Exploring the Link Between Vitamin D Deficiency and Obstructive Sleep Apnea: A Comprehensive Review — Journal of Sleep Research, 2024 doi
- 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines — 2023 doi
- Cardiovascular Safety of Testosterone-Replacement Therapy — The New England Journal of Medicine, 2023 doi
- Increasing Equity of Physical Activity Promotion for Optimal Cardiovascular Health in Adults: A Scientific Statement From the American Heart Association — Circulation, 2023 doi
- Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association — Circulation, 2023 doi
- Diagnostic Evaluation of Sexual Dysfunction in the Male Partner in the Setting of Infertility: A Committee Opinion — Fertility and Sterility, 2023 doi
- Obstructive Sleep Apnea and Serum Total Testosterone: A System Review and Meta-Analysis — Sleep & Breathing = Schlaf & Atmung, 2023 doi
- The Role of Magnesium in Sleep Health: A Systematic Review of Available Literature — Biological Trace Element Research, 2023 doi
- Sustained Improvements in the Cardiometabolic Profile of Patients With Obstructive Sleep Apnea After a Weight-Loss Mediterranean Diet/Lifestyle Intervention: 12-Month Follow-Up (6 Months Post-Intervention) of the "MIMOSA" Randomized Clinical Trial — Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 2023 doi
- The Effects of Sleep Deprivation and Obstructive Sleep Apnea Syndrome on Male Reproductive Function: A Multi-Arm Randomised Trial — Journal of Sleep Research, 2023 doi
- Nutritional Modulation of Sleep Latency, Duration, and Efficiency: A Randomized, Repeated-Measures, Double-Blind Deception Study — Medicine and Science in Sports and Exercise, 2023 doi
- Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force — JAMA, 2022 doi
- Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement — JAMA, 2022 doi
- Role of Coronary Artery Calcium Testing for Risk Assessment in Primary Prevention of Atherosclerotic Cardiovascular Disease: A Review — JAMA Cardiology, 2022 doi
- Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease — JAMA Network Open, 2022 doi
- Comparison of American and European Guidelines for Primary Prevention of Cardiovascular Disease: JACC Guideline Comparison — Journal of the American College of Cardiology, 2022 doi
- Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association — Circulation, 2022 doi
- Interactions Between Erectile Dysfunction, Cardiovascular Disease and Cardiovascular Drugs — Cardiology, 2022 doi
- The Effect of Low-Intensity Shock Wave Therapy on Moderate Erectile Dysfunction: A Double-Blind, Randomized, Sham-Controlled Clinical Trial — The Journal of Urology, 2022 doi
- Effect of an Interdisciplinary Weight Loss and Lifestyle Intervention on Obstructive Sleep Apnea Severity: The INTERAPNEA Randomized Clinical Trial — JAMA Network Open, 2022 doi
- Sleep, testosterone and cortisol balance, and ageing men — Reviews in Endocrine & Metabolic Disorders, 2022 doi
- Association of Magnesium Intake With Sleep Duration and Sleep Quality: Findings From the CARDIA Study — Sleep, 2022 doi
- Dose-Response Relationship Between Weight Loss and Improvements in Obstructive Sleep Apnea Severity After a Diet/Lifestyle Interventions: Secondary Analyses of the "MIMOSA" Randomized Clinical Trial — Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine, 2022 doi
- Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals With Non-Optimal Lipid Levels? — Current Atherosclerosis Reports, 2021 doi
- Coronary Artery Calcium: Where Do We Stand After Over 3 Decades? — The American Journal of Medicine, 2021 doi
- Cardiovascular Impact of Nutritional Supplementation With Omega-3 Fatty Acids: JACC Focus Seminar — Journal of the American College of Cardiology, 2021 doi
- 2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association — 2021 doi
- Physical Activity as a Critical Component of First-Line Treatment for Elevated Blood Pressure or Cholesterol: Who, What, and How?: A Scientific Statement From the American Heart Association — : 1979), 2021 doi
- Penile low intensity shock wave treatment for PDE5I refractory erectile dysfunction: a randomized double-blind sham-controlled clinical trial — World Journal of Urology, 2021 doi
- 2021 ESC Guidelines on Cardiovascular Disease Prevention in Clinical Practice — 2021 doi
- A Weight-Loss Mediterranean Diet/Lifestyle Intervention Ameliorates Inflammation and Oxidative Stress in Patients With Obstructive Sleep Apnea: Results of the "MIMOSA" Randomized Clinical Trial — European Journal of Nutrition, 2021 doi
- The Effectiveness of a Weight-Loss Mediterranean Diet/Lifestyle Intervention in the Management of Obstructive Sleep Apnea: Results of the "MIMOSA" Randomized Clinical Trial — Clinical Nutrition (Edinburgh, Scotland), 2021 doi
- Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review — Journal of the American College of Cardiology, 2021 doi
- Changes in cortisol levels by continuous positive airway pressure in patients with obstructive sleep apnoea: Meta‐analysis of 637 individuals — Clinical Endocrinology, 2021 doi
- Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association — Circulation, 2021 doi
- Effect of Bergamot on Lipid Profile in Humans: A Systematic Review — Critical Reviews in Food Science and Nutrition, 2020 doi
- Association of Diet With Erectile Dysfunction Among Men in the Health Professionals Follow-up Study — JAMA Network Open, 2020 doi
- Lifestyles and sexuality in men and women: the gender perspective in sexual medicine — Reproductive Biology and Endocrinology : RB&E, 2020 doi
- Diagnosis and Management of Obstructive Sleep Apnea: A Review — JAMA, 2020 doi
- Educational, Supportive and Behavioural Interventions to Improve Usage of Continuous Positive Airway Pressure Machines in Adults With Obstructive Sleep Apnoea — The Cochrane Database of Systematic Reviews, 2020 doi
- Influence of Dietary Sources of Melatonin on Sleep Quality: A Review — Journal of Food Science, 2020 doi
- Lipoprotein(a): Current Evidence for a Physiologic Role and the Effects of Nutraceutical Strategies — Clinical Therapeutics, 2019 doi
- 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines — 2019 doi
- Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia — The New England Journal of Medicine, 2019 doi
- Effects of a New Combination of Medical Food on Endothelial Function and Lipid Profile in Dyslipidemic Subjects: A Pilot Randomized Trial — BioMed Research International, 2019 doi
- 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines — 2019 doi
- Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map — Annals of Internal Medicine, 2019 doi
- Clinical studies on low intensity extracorporeal shockwave therapy for erectile dysfunction: a systematic review and meta-analysis of randomised controlled trials — International Journal of Impotence Research, 2019 doi
- Current guideline recommendations and analysis of evidence quality on low-intensity shockwave therapy for erectile dysfunction — International Journal of Impotence Research, 2019 doi
- Positional Therapy for Obstructive Sleep Apnoea — The Cochrane Database of Systematic Reviews, 2019 doi
- Clinical Use of the STOP-BANG Questionnaire to Determine Postoperative Risk in Veterans — The Laryngoscope, 2019 doi
- Psychotropic Effects of -Theanine and Its Clinical Properties: From the Management of Anxiety and Stress to a Potential Use in Schizophrenia — Pharmacological Research, 2019 doi
- Obstructive Sleep Apnea in Adults — The New England Journal of Medicine, 2019 doi
- Weight Loss and Lifestyle Interventions for Obstructive Sleep Apnoea in Adults: Systematic Review and Meta-Analysis — Obesity Reviews : An Official Journal of the International Association for the Study of Obesity, 2019 doi
- A Clinical Perspective of Sleep and Andrological Health: Assessment, Treatment Considerations, and Future Research — The Journal of Clinical Endocrinology and Metabolism, 2019 doi
- Effects of CPAP on Testosterone Levels in Patients With Obstructive Sleep Apnea: A Meta-Analysis Study — Frontiers in Endocrinology, 2019 doi
- Cardiovascular Disease Prevention by Diet Modification: JACC Health Promotion Series — Journal of the American College of Cardiology, 2018 doi
- The Role of Nutraceuticals in Statin Intolerant Patients — Journal of the American College of Cardiology, 2018 doi
- Reprint Of: Cardiovascular Disease Prevention by Diet Modification: JACC Health Promotion Series — Journal of the American College of Cardiology, 2018 doi
- 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines — 2018 doi
- Erectile Dysfunction: AUA Guideline — The Journal of Urology, 2018 doi
- Vitamin D and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis — Sleep Medicine, 2018 doi
- The Role of Weight Management in the Treatment of Adult Obstructive Sleep Apnea — American Journal of Respiratory and Critical Care Medicine, 2018 doi
- Low-Intensity Extracorporeal Shock Wave Treatment Improves Erectile Function: A Systematic Review and Meta-Analysis — European Urology, 2017 doi
- An Update on the Various Practical Applications of the STOP-Bang Questionnaire in Anesthesia, Surgery, and Perioperative Medicine — Current Opinion in Anaesthesiology, 2017 doi
- Diet and Exercise in the Management of Obstructive Sleep Apnoea and Cardiovascular Disease Risk — European Respiratory Review : An Official Journal of the European Respiratory Society, 2017 doi
- Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline — Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine, 2017 doi
- Efficacy of Nasal Continuous Positive Airway Pressure on Patients With OSA With Erectile Dysfunction and Low Sex Hormone Levels — Respiratory Medicine, 2016 doi
- Sleep Apnoea and the Hypothalamic-Pituitary-Adrenal Axis in Men and Women: Effects of Continuous Positive Airway Pressure — The European Respiratory Journal, 2016 doi
- STOP-Bang Questionnaire: A Practical Approach to Screen for Obstructive Sleep Apnea — Chest, 2016 doi
- The Sleep-Promoting and Hypothermic Effects of Glycine Are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus — Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 2015 doi
- The role of cherries in exercise and health — Scandinavian Journal of Medicine & Science in Sports, 2014 doi
- Efficacy of Continuous Positive Airway Pressure on Testosterone in Men With Obstructive Sleep Apnea: A Meta-Analysis — PloS One, 2014 doi
- Diagnosis of Obstructive Sleep Apnea in Adults: A Clinical Practice Guideline From theAmerican College of Physicians — Annals of Internal Medicine, 2014 doi
- Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia — Journal of Pineal Research, 2013 doi
- Restoring the Salivary Cortisol Awakening Response Through Nasal Continuous Positive Airway Pressure Therapy in Obstructive Sleep Apnea — Chronobiology International, 2013 doi
- The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease — Mayo Clinic Proceedings, 2012 doi
- Effect of Tart Cherry Juice (Prunus Cerasus) on Melatonin Levels and Enhanced Sleep Quality — European Journal of Nutrition, 2012 doi
- High STOP-Bang Score Indicates a High Probability of Obstructive Sleep Apnoea — British Journal of Anaesthesia, 2012 doi
- New Therapeutic Strategy for Amino Acid Medicine: Glycine Improves the Quality of Sleep — Journal of Pharmacological Sciences, 2012 doi
- The Effect of Lifestyle Modification and Cardiovascular Risk Factor Reduction on Erectile Dysfunction: A Systematic Review and Meta-analysis — Archives of Internal Medicine, 2011 doi
- Orexin Neurons Receive Glycinergic Innervations — PloS One, 2011 doi
- Hypothalamic-Pituitary-Adrenal Axis Activation in Obstructive Sleep Apnea: The Effect of Continuous Positive Airway Pressure Therapy — The Journal of Clinical Endocrinology and Metabolism, 2009 doi
- Neuroendocrine Dysfunction in Sleep Apnea: Reversal by Continuous Positive Airways Pressure Therapy — The Journal of Clinical Endocrinology and Metabolism, 1989 doi
The strength of this evidence varies: some are large reviews and meta-analyses, some are small single studies. The steps in the article are simple, low-risk self-care measures, not treatment, and they may not suit everyone.
This is general information, not a prescription. Tests and treatment are chosen by a doctor.