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Что такое перименопауза и как её узнать

4 минуты чтенияПроверено специалистом VIA-L · 17.10.2026

Сон стал хуже, месячные — непредсказуемее, настроение скачет, а анализы «в порядке». Знакомо? Очень часто за этим стоит перименопауза — переходные годы перед последними месячными. Это не болезнь, а этап, через который проходит каждая женщина. Но о нём почти не говорят, поэтому многие годами не понимают, что с ними происходит.

Что происходит в теле

В переходе гормоны меняются не плавно и не одновременно.

Прогестерон падает первым и ровно. После 40 всё больше циклов проходит без овуляции — и это обычная часть перехода. Прогестерон питает естественный «успокоитель» мозга, поэтому его спад чаще всего чувствуется как трудное засыпание.

Эстроген в это время не падает, а качается. Он то снижается, то скачет выше обычного, и только потом уходит вниз окончательно. Главное, что раскачивает самочувствие в эти годы, — именно амплитуда качелей, а не сам уровень. Отсюда и ощущение, что «ничего не понятно»: одна неделя хорошая, следующая — тяжёлая.

Как её узнать

Перименопаузу узнают по картине, которая складывается во времени, а не по одному анализу. Типичные сигналы:

Не обязательно, чтобы было всё сразу. Важнее рисунок: что повторяется и как это связано с циклом.

Что сделать в первую очередь

Начать отмечать. Первый день месячных, сон, приливы, настроение — каждый день, коротко. Через несколько недель видна связь, которую в памяти не удержать. Именно это и есть лучший «анализ» перехода.

Поставить якорь сна. Подъём в одно и то же время все семь дней недели, включая выходные, и 10–15 минут дневного света в первый час после подъёма. Это самый сильный поведенческий рычаг для сна — сильнее любых добавок.

Убрать то, что раскачивает ночь. Кофе и крепкий чай — до 14:00, вечером — без алкоголя: он усыпляет, но режет вторую половину ночи.

Проверить железо при обильных месячных. Обильные месячные — самая частая причина нехватки железа у женщин, и его запасы падают раньше, чем меняются обычные анализы крови. Усталость, одышка на лестнице, выпадение волос — повод попросить у врача анализ на ферритин. Железо — по анализу, не вслепую.

Когда к врачу без промедления

Это не «просто переход» — такие сигналы нужно показать гинекологу.

Что попробовать на этой неделе

На чём основано

Статья написана по темам базы знаний VIA-L. За ними стоят опубликованные работы — вот они:

  1. Cognitive Behavioural Therapeutics for Insomnia Symptoms in the Perimenopause Through to the Early Postmenopausal Period — The Cochrane Database of Systematic Reviews, 2026 doi
  2. Real-World Safety Profile of Fezolinetant: A Disproportionality Analysis Based on the FAERS Database — Naunyn-Schmiedeberg's Archives of Pharmacology, 2026 doi
  3. Integrative Approaches to Perimenopause — The American Journal of Medicine, 2026 doi
  4. Effect of Lactobacillus-Based Probiotics on Genitourinary Syndrome of Menopause in Post-Menopausal Women: A Systematic Review — Maturitas, 2026 doi
  5. Hepatic Adverse Event Signals of Fezolinetant in Real-World Use Based on Postmarketing Surveillance — Obstetrics and Gynecology, 2026 doi
  6. Integrative Medicine Approaches for Menopause — Obstetrics and Gynecology, 2026 doi
  7. Reframing menopause and menopause hormone therapy as opportunities for healthy aging — Science, 2026 doi
  8. Cognitive-Behavioral, Acceptance-Based, and Mindfulness-Based Interventions for Psychological and Sleep-Related Symptoms During Menopause: A Systematic Review — Acta Psychologica, 2026 doi
  9. Effectiveness of Non-Pharmacological Interventions for Insomnia Related to Natural Menopause: A Meta-Analysis of Randomized Controlled Trials — Maturitas, 2026 doi
  10. Nutritional Modulators of Sleep: A Narrative Review of Vitamins, Minerals, Amino Acids, and Their Neurobiological and Chronoepigenetic Mechanisms — Chronobiology International, 2026 doi
  11. Insomnia and women: exploring vulnerability, impact, and intervention — Sleep & Breathing = Schlaf & Atmung, 2026 doi
  12. OSA in Women: Associations With Reproductive Aging and Screening Challenges — Chest, 2026 doi
Показать все (132)
  1. Pharmacological and Non-Pharmacological Treatments for Chronic Insomnia in Perimenopausal and Postmenopausal Women: A Systematic Review and Meta-Analysis — Sleep Medicine, 2026 doi
  2. Cost-Effectiveness of First-Line IV vs Oral Iron for Iron-Deficiency Anemia in Women With Heavy Menstrual Bleeding — Blood Advances, 2026 doi
  3. FDA Approves Nonhormonal Treatment for Menopausal Hot Flashes — JAMA, 2025 doi
  4. Nonhormonal Treatment of Menopausal Vasomotor Symptoms — JAMA Internal Medicine, 2025 doi
  5. Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause: A Phase 3 Randomized Clinical Trial — JAMA Internal Medicine, 2025 doi
  6. Self-Administered Hypnosis vs Sham Hypnosis for Hot Flashes — JAMA Network Open, 2025 doi
  7. Safety of Fezolinetant for Treatment of Moderate to Severe Vasomotor Symptoms Due to Menopause: Pooled Analysis of Three Randomized Phase 3 Studies — Advances in Therapy, 2025 doi
  8. Advances in Pharmacotherapy for Menopausal Vasomotor Symptoms — Drugs, 2025 doi
  9. Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials — Advances in Nutrition (Bethesda, Md.), 2025 doi
  10. Evidence-Based Guideline: Premature Ovarian Insufficiency — Fertility and Sterility, 2025 doi
  11. The Effectiveness of Mindfulness-Based Interventions on Menopausal Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials — Journal of Affective Disorders, 2025 doi
  12. The Role of Lifestyle Medicine in Menopausal Health: A Review of Non-Pharmacologic Interventions — Climacteric : The Journal of the International Menopause Society, 2025 doi
  13. European Society of Endocrinology Clinical Practice Guideline for Evaluation and Management of Menopause and the Perimenopause — European Journal of Endocrinology, 2025 doi
  14. Fezolinetant and Elinzanetant Therapy for Menopausal Women Experiencing Vasomotor Symptoms: A Systematic Review and Meta-Analysis — Obstetrics and Gynecology, 2025 doi
  15. Gut Microbiota Has the Potential to Improve Health of Menopausal Women by Regulating Estrogen — Frontiers in Endocrinology, 2025 doi
  16. Natural Strategies to Optimize Estrogen Levels in Aging Women: Mini Review — Frontiers in Aging, 2025 doi
  17. Effects of Soy Isoflavones on Menopausal Symptoms in Perimenopausal Women: A Systematic Review and Meta-Analysis — PeerJ, 2025 doi
  18. Infertility Evaluation and Treatment — The New England Journal of Medicine, 2025 doi
  19. Effect of a Novel Nutraceutical Combination of EstroG-100 and Γ-Aminobutyric Acid (GABA) in Attenuating Symptoms of Menopause in Healthy Adult Women: A Randomized Double-Blinded Placebo-Controlled Study — Menopause (New York, N.Y.), 2025 doi
  20. Menopause and Movement: Exercise for Better Sleep and Psychological Well-Being-a Systematic Review — Menopause (New York, N.Y.), 2025 doi
  21. Omega-3 Fatty Acids and Sleep: Recent Advances in Understanding Effects and Mechanisms — Current Opinion in Clinical Nutrition and Metabolic Care, 2025 doi
  22. Iron Deficiency in Adults: A Review — JAMA, 2025 doi
  23. Psychiatric and Cognitive Outcomes of Iron Supplementation in Non-Anemic Children, Adolescents, and Menstruating Adults: A Meta-Analysis and Systematic Review — Neuroscience and Biobehavioral Reviews, 2025 doi
  24. Comparison of diagnostic algorithms used in guidelines on nutritional anaemias in adults — PloS One, 2025 doi
  25. An Empowerment Model for Managing Menopause — Lancet (London, England), 2024 doi
  26. "Not feeling like myself" in perimenopause - what does it mean? Observations from the Women Living Better survey — Menopause, 2024 doi
  27. Mapping Global Prevalence of Menopausal Symptoms Among Middle-Aged Women: A Systematic Review and Meta-Analysis — BMC Public Health, 2024 doi
  28. Components and Delivery Formats of Cognitive Behavioral Therapy for Chronic Insomnia in Adults — JAMA Psychiatry, 2024 doi
  29. Network Meta-Analysis Examining Efficacy of Components of Cognitive Behavioural Therapy for Insomnia — Clinical Psychology Review, 2024 doi
  30. Effects of Mind-Body Exercise on Perimenopausal and Postmenopausal Women: A Systematic Review and Meta-Analysis — Menopause (New York, N.Y.), 2024 doi
  31. Stimulus control for insomnia: A systematic review and meta-analysis — J Sleep Res, 2024 doi
  32. Social jetlag and obesity: A systematic review and meta-analysis — Obes Rev, 2024 doi
  33. The Modern Management of Uterine Fibroids-Related Abnormal Uterine Bleeding — Fertility and Sterility, 2024 doi
  34. ACR Appropriateness Criteria® Management of Uterine Fibroids: 2023 Update — Journal of the American College of Radiology : JACR, 2024 doi
  35. A clinical study evaluating low dose ferrous fumarate vs — Scientific Reports, 2024 doi
  36. Identification and management of preoperative anaemia in adults: A British Society for Haematology Guideline update — British Journal of Haematology, 2024 doi
  37. Management of Menopausal Symptoms: A Review — JAMA, 2023 doi
  38. Premenstrual Disorders, Timing of Menopause, and Severity of Vasomotor Symptoms — JAMA Network Open, 2023 doi
  39. Effects of transdermal versus oral hormone replacement therapy in postmenopause: a systematic review — Archives of Gynecology and Obstetrics, 2023 doi
  40. Fezolinetant: First Approval — Drugs, 2023 doi
  41. EMAS Position Statement: Vitamin D and Menopausal Health — Maturitas, 2023 doi
  42. Resistance Training for Postmenopausal Women: Systematic Review and Meta-Analysis — Menopause (New York, N.Y.), 2023 doi
  43. A Dietary Intervention for Vasomotor Symptoms of Menopause: A Randomized, Controlled Trial — Menopause (New York, N.Y.), 2023 doi
  44. Black Cohosh Extracts in Women With Menopausal Symptoms: An Updated Pairwise Meta-Analysis — Menopause (New York, N.Y.), 2023 doi
  45. The 2023 Nonhormone Therapy Position Statement of the North American Menopause Society — Menopause (New York, N.Y.), 2023 doi
  46. Rethinking Menopausal Hormone Therapy: For Whom, What, When and How long? — Circulation, 2023 doi
  47. Effect of hysterectomy on ovarian function: a systematic review and meta-analysis — J Ovarian Res, 2023 doi
  48. Oral Micronized Progesterone for Perimenopausal Night Sweats and Hot Flushes a Phase III Canada-Wide Randomized Placebo-Controlled 4 month Trial — Scientific Reports, 2023 doi
  49. Effects of Sleep Fragmentation and Estradiol Decline on Cortisol in a Human Experimental Model of Menopause — The Journal of Clinical Endocrinology and Metabolism, 2023 doi
  50. Changes in Cortisol Awakening Responses (CAR) in Menopausal Women Through Short-Term Marine Healing Retreat Program With Specific Factors Affecting Each CAR Index — PloS One, 2023 doi
  51. Progesterone and Its Metabolites Play a Beneficial Role in Affect Regulation in the Female Brain — Pharmaceuticals (Basel, Switzerland), 2023 doi
  52. GABA-ergic Modulators: New Therapeutic Approaches to Premenstrual Dysphoric Disorder — CNS Drugs, 2023 doi
  53. The Effect of Caffeine on Subsequent Sleep: A Systematic Review and Meta-Analysis — Sleep Medicine Reviews, 2023 doi
  54. Clinical and cost-effectiveness of nurse-delivered sleep restriction therapy for insomnia in primary care (HABIT): a pragmatic, superiority, open-label, randomised controlled trial — Lancet, 2023 doi
  55. Optimizing Sleep Across the Menopausal Transition — Climacteric : The Journal of the International Menopause Society, 2023 doi
  56. Relationship between daytime napping with the occurrence and development of diabetes: a systematic review and meta-analysis — BMJ Open, 2023 doi
  57. The Relationship Between Heavy Menstrual Bleeding, Iron Deficiency, and Iron Deficiency Anemia — American Journal of Obstetrics and Gynecology, 2023 doi
  58. Oral Gonadotropin-Releasing Hormone Antagonists for the Treatment of Uterine Leiomyomas — Obstetrics and Gynecology, 2023 doi
  59. Efficacy of Cognitive Therapy and Behavior Therapy for Menopausal Symptoms: A Systematic Review and Meta-Analysis — Psychological Medicine, 2022 doi
  60. Effects of Exercise on Vasomotor Symptoms in Menopausal Women: A Systematic Review and Meta-Analysis — Climacteric : The Journal of the International Menopause Society, 2022 doi
  61. Results of a Pilot Study of a Cooling Mattress Pad to Reduce Vasomotor Symptoms and Improve Sleep — Menopause (New York, N.Y.), 2022 doi
  62. Resistance Training Reduced Luteinising Hormone Levels in Postmenopausal Women in a Substudy of a Randomised Controlled Clinical Trial: A Clue to How Resistance Training Reduced Vasomotor Symptoms — PloS One, 2022 doi
  63. Relating Neurosteroid Modulation of Inhibitory Neurotransmission to Behaviour — Journal of Neuroendocrinology, 2022 doi
  64. Role of Inflammation, Oxidative Stress, and Mitochondrial Changes in Premenstrual Psychosomatic Behavioral Symptoms with Anti‐Inflammatory, Antioxidant Herbs, and Nutritional Supplements — Oxidative Medicine and Cellular Longevity, 2022 doi
  65. Systematic review and meta-analyses on the effects of afternoon napping on cognition — Sleep Med Rev, 2022 doi
  66. A Portrait of Obstructive Sleep Apnea Risk Factors in 27,210 Middle-Aged and Older Adults in the Canadian Longitudinal Study on Aging — Scientific Reports, 2022 doi
  67. Disruption of Sleep Continuity During the Perimenopause: Associations With Female Reproductive Hormone Profiles — The Journal of Clinical Endocrinology and Metabolism, 2022 doi
  68. Interventions for heavy menstrual bleeding; overview of Cochrane reviews and network meta‐analysis — Cochrane Database of Systematic Reviews, 2022 doi
  69. Iron Deficiency Anemia: Impact on Women's Reproductive Health — Fertility and Sterility, 2022 doi
  70. Uterine bleeding: how understanding endometrial physiology underpins menstrual health — Endocrinology, 2022 doi
  71. Guideline for the laboratory diagnosis of iron deficiency in adults (excluding pregnancy) and children — British Journal of Haematology, 2022 doi
  72. Iron deficiency screening is a key issue in chronic inflammatory diseases: A call to action — Journal of Internal Medicine, 2022 doi
  73. The Effect of Vitamin MK-7 on Bone Mineral Density and Microarchitecture in Postmenopausal Women With Osteopenia, a 3-Year Randomized, Placebo-Controlled Clinical Trial — Osteoporosis International : A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2021 doi
  74. Cognitive Behavioral Therapy for Menopausal Symptoms — Climacteric : The Journal of the International Menopause Society, 2021 doi
  75. Diagnosis and Treatment of Luteal Phase Deficiency: A Committee Opinion — Fertility and Sterility, 2021 doi
  76. Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial — JAMA, 2021 doi
  77. Omega-3 Fatty Acids for Depression in Adults — The Cochrane Database of Systematic Reviews, 2021 doi
  78. Omega-3 Long-Chain Polyunsaturated Fatty Acid and Sleep: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Longitudinal Studies — Nutrition Reviews, 2021 doi
  79. Sleep During Menopausal Transition: A 10-Year Follow-Up — Sleep, 2021 doi
  80. Effects of a Short Daytime Nap on the Cognitive Performance: A Systematic Review and Meta-Analysis — Int J Environ Res Public Health, 2021 doi
  81. A Review of Clinical Guidelines on the Management of Iron Deficiency and Iron-Deficiency Anemia in Women With Heavy Menstrual Bleeding — Advances in Therapy, 2021 doi
  82. The Effect of Oral Capsule of Curcumin and Vitamin E on the Hot Flashes and Anxiety in Postmenopausal Women: A Triple Blind Randomised Controlled Trial — Complementary Therapies in Medicine, 2020 doi
  83. Altered Activity of Xenobiotic Detoxifying Enzymes at Menopause - A Cross-Sectional Study — Environmental Research, 2020 doi
  84. Calcium, Vitamin D, Vitamin K2, and Magnesium Supplementation and Skeletal Health — Maturitas, 2020 doi
  85. Hormone Therapy for Postmenopausal Women — The New England Journal of Medicine, 2020 doi
  86. Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association — Circulation, 2020 doi
  87. American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis-2020 Update — Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2020 doi
  88. The Allopregnanolone to Progesterone Ratio Across the Menstrual Cycle and in Menopause — Psychoneuroendocrinology, 2020 doi
  89. The Effects of Dietary Nutrition on Sleep and Sleep Disorders — Mediators of Inflammation, 2020 doi
  90. Assessment and Management of Heavy Menstrual Bleeding — JAMA, 2020 doi
  91. Soy Intake and Vasomotor Menopausal Symptoms Among Midlife Women: A Pooled Analysis of Five Studies From the InterLACE Consortium — European Journal of Clinical Nutrition, 2019 doi
  92. Pheochromocytoma and Paraganglioma — The New England Journal of Medicine, 2019 doi
  93. Allopregnanolone and Reproductive Psychiatry: An Overview — International Review of Psychiatry (Abingdon, England), 2019 doi
  94. Chronotype and Social Jetlag: A (Self-) Critical Review — Biology (Basel), 2019 doi
  95. Abnormal Uterine Bleeding in Reproductive-Age Women — JAMA, 2019 doi
  96. Screening and Management of Bleeding Disorders in Adolescents With Heavy Menstrual Bleeding: ACOG COMMITTEE OPINION, Number 785 — Obstetrics and Gynecology, 2019 doi
  97. Effect of Omega-3 Supplements on Vasomotor Symptoms in Menopausal Women: A Systematic Review and Meta-Analysis — European Journal of Obstetrics, Gynecology, and Reproductive Biology, 2018 doi
  98. Mindfulness-Based Stress Reduction (MBSR) or Psychoeducation for the Reduction of Menopausal Symptoms: A Randomized, Controlled Clinical Trial — Scientific Reports, 2018 doi
  99. Symptoms of menopause — global prevalence, physiology and implications — Endocrinology, 2018 doi
  100. Effects of Pharmacologic and Nonpharmacologic Interventions on Insomnia Symptoms and Self-Reported Sleep Quality in Women With Hot Flashes: A Pooled Analysis of Individual Participant Data From Four MsFLASH Trials — Sleep, 2018 doi
  101. Antifibrinolytics for heavy menstrual bleeding — Cochrane Database of Systematic Reviews, 2018 doi
  102. Effects of low‐to‐moderate alcohol supplementation on urinary estrogen metabolites in postmenopausal women in a controlled feeding study — Cancer Medicine, 2017 doi
  103. Why Are Women So Vulnerable to Anxiety, Trauma-Related and Stress-Related Disorders? The Potential Role of Sex Hormones — Psychiatry, 2017 doi
  104. Omega-3 Versus Isoflavones in the Control of Vasomotor Symptoms in Postmenopausal Women — Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology, 2017 doi
  105. Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis — JAMA, 2016 doi
  106. Surgery versus medical therapy for heavy menstrual bleeding — Cochrane Database of Systematic Reviews, 2016 doi
  107. Non‐anaemic iron deficiency – a disease looking for recognition of diagnosis: a systematic review — European Journal of Haematology, 2016 doi
  108. Duration of menopausal vasomotor symptoms over the menopause transition — JAMA Intern Med, 2015 doi
  109. Pooled Analysis of Six Pharmacologic and Nonpharmacologic Interventions for Vasomotor Symptoms — Obstetrics and Gynecology, 2015 doi
  110. Exercise for vasomotor menopausal symptoms — Cochrane Database of Systematic Reviews, 2014 doi
  111. Luteal Phase Deficiency in Regularly Menstruating Women: Prevalence and Overlap in Identification Based on Clinical and Biochemical Diagnostic Criteria — The Journal of Clinical Endocrinology and Metabolism, 2014 doi
  112. Efficacy of Omega-3 for Vasomotor Symptoms Treatment: A Randomized Controlled Trial — Menopause (New York, N.Y.), 2014 doi
  113. Fruit, Mediterranean-Style, and High-Fat and -Sugar Diets Are Associated With the Risk of Night Sweats and Hot Flushes in Midlife: Results From a Prospective Cohort Study — The American Journal of Clinical Nutrition, 2013 doi
  114. Practice Bulletin No — Obstetrics and Gynecology, 2012 doi
  115. Perceived Control, Lifestyle, Health, Socio-Demographic Factors and Menopause: Impact on Hot Flashes and Night Sweats — Maturitas, 2011 doi
  116. Protective role of melatonin in progesterone production by human luteal cells — Journal of Pineal Research, 2011 doi
  117. Pathophysiology and Treatment of Menopausal Hot Flashes — Seminars in Reproductive Medicine, 2005 doi
  118. Is This Woman Perimenopausal? — JAMA, 2003 doi
  119. Diagnostic Role of Follicle-Stimulating Hormone (FSH) Measurements During the Menopausal Transition--an Analysis of FSH, Oestradiol and Inhibin — European Journal of Endocrinology, 1994 doi
  120. The Association Between Moderate Alcoholic Beverage Consumption and Serum Estradiol and Testosterone Levels in Normal Postmenopausal Women: Relationship to the Literature — Alcoholism, Clinical and Experimental Research, 1992 doi

Доказательная сила у этих работ разная: где-то крупные обзоры и мета-анализы, где-то отдельные небольшие исследования. Шаги в статье — простые меры заботы о себе с низким риском, а не лечение, и подходят не всем.

Это общие сведения, а не назначение. Обследование и лечение подбирает врач.

Приложение VIA-L

VIA-L — приложение для женщин с 35 и мужчин с 40 лет: сон, энергия, настроение и тело в период гормональных перемен. Простыми словами, по вашим данным — и с проверкой, что помогло.

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