No energy after 40: where men's fatigue comes from and what brings it back
You wake up already tired, get through the morning on coffee, and by evening only have the energy for the couch. The first thing that comes to mind is "age", "the adrenals" or "testosterone". In reality, fatigue almost always has specific causes you can fix.
"Adrenal fatigue" is a myth
There's no such diagnosis: endocrinologists have rejected it, and there are no valid tests for it. "Adrenal support" supplements don't help and sometimes contain hidden hormones. The main harm of the myth is that it takes time away from the real cause.
The fatigue itself is real. You just need to look for it somewhere else.
What most often lies behind fatigue
- Sleep and apnea. Broken sleep and breathing pauses at night are a common and almost always undiagnosed cause. More in the article "Sleep after 40".
- Mood. In men, depression often looks not like sadness but like "no energy", irritability and loss of interest.
- Belly and metabolism. Fat around the waist and sugar spikes steal your energy on their own.
- Testosterone. It drops with short sleep, stress and extra weight — and comes back when the cause goes away.
- Medicines and alcohol. An evening "drink to relax" makes sleep and recovery worse.
Thyroid disease is rare in men, so "it's all the thyroid" is more the exception than the rule. A doctor checks it with a blood test, not by symptoms.
Signs that call for a test, not "pushing through"
- Vitamin B12: numbness or tingling in the hands and feet; the risk is higher with metformin, heartburn medicines and a vegan diet.
- Anaemia: paleness, breathlessness on the stairs. Iron deficiency in a man is never normal — it's always a reason to get checked.
- Breathing during sleep: loud snoring with pauses, sleep that doesn't refresh.
What brings your energy back
Movement. For a man over 40, the risk of moving too little is far higher than the risk of "overdoing it". Regular training lowers resting stress hormones, and an easy walk lowers them straight away.
Sleep and its regularity. Get up at the same time all seven days, 7 or more hours. Short sleep raises evening stress hormones and lowers testosterone.
An evening without alcohol. It delays the drop in stress hormones and cuts into the second half of the night. One of the most rewarding free steps.
Coffee in the morning. Daytime coffee keeps pushing stress hormones up. Moving your coffee earlier pays off more than taking "anti-stress" supplements.
Slow breathing. About six breaths a minute for five minutes — it eases tension within minutes.
What about supplements?
"Adaptogens" is a marketing word, not a group of medicines. We don't recommend ashwagandha: the effect is modest and the risks for the liver and the thyroid are real. Magnesium makes sense only if you get too little from food. "Testosterone boosters" don't treat fatigue.
When to see a doctor
- Rapid weight gain together with muscle weakness, purple stretch marks, easy bruising.
- Darker skin, dizziness when standing up, salt cravings, unexplained weight loss, nausea.
- Unexplained weight loss or anaemia.
- Breathlessness, chest pain or palpitations — urgently.
What to try this week
- Get up at the same time all seven days.
- Last coffee before lunch, an evening without alcohol.
- A 10–15 minute walk after your main meals.
What this is based on
This article is based on topics from the VIA-L knowledge base. These are the published studies behind them:
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- Impact of GLP-1 and Dual Agonists on the Incidence Of new Cases of Physician-Reported Sleep Apnea: A Real-World Study — Annals of the American Thoracic Society, 2026 doi
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- An Integrative Approach to HPA Axis Dysfunction: From Recognition to Recovery — The American Journal of Medicine, 2025 doi
- Dietary Patterns and Testosterone Balance: A Review of Clinical Data and Perspectives — Journal of Advanced Research, 2025 doi
- L-Theanine: From Tea Leaf to Trending Supplement - Does the Science Match the Hype for Brain Health and Relaxation? — Nutrition Research (New York, N.Y.), 2025 doi
- Longitudinal Evaluation of Reproductive Endocrine Function in Men With ACTH-Dependent Cushing Syndrome — The Journal of Clinical Endocrinology and Metabolism, 2025 doi
- Diagnosis and Treatment of Obstructive Sleep Apnea — JAMA Internal Medicine, 2025 doi
- Unraveling the Connection Between the Mediterranean Diet and Sleep Health: From Biological Mechanisms to Clinical Implications — Sleep & Breathing = Schlaf & Atmung, 2025 doi
- Magnesium Is a Key Trace Element in Obstructive Sleep Apnea: Evidence From Mendelian Randomization Analysis and NHANES Database — Respiratory Medicine, 2025 doi
- The Effects of L-Theanine Consumption on Sleep Outcomes: A Systematic Review and Meta-Analysis — Sleep Medicine Reviews, 2025 doi
- Efficacy of Incretin-Based Therapies in Obesity-Related Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials — Sleep Medicine Reviews, 2025 doi
- Examining the Effect of L-Theanine on Sleep: A Systematic Review of Dietary Supplementation Trials — Nutritional Neuroscience, 2025 doi
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- Testosterone Treatment in Middle-Aged and Older Men with Hypogonadism — The New England Journal of Medicine, 2025 doi
- Semaglutide improved sperm morphology in obese men with type 2 diabetes mellitus and functional hypogonadism — Diabetes, Obesity & Metabolism, 2025 doi
- Shoden Promotes Relief From Stress and Anxiety: A Randomized, Double-Blind, Placebo-Controlled Study on Healthy Subjects With High Stress Levels — Heliyon, 2024 doi
- Effectiveness of Stress Management Interventions to Change Cortisol Levels: A Systematic Review and Meta-Analysis — Psychoneuroendocrinology, 2024 doi
- Prevalence and Outcome of Secondary Hypogonadism in Male Patients With Cushing's Syndrome and Mild Autonomous Cortisol Secretion — European Journal of Endocrinology, 2024 doi
- Treatment of OSA and Its Impact on Cardiovascular Disease, Part 2: JACC State-of-the-Art Review — Journal of the American College of Cardiology, 2024 doi
- Sleep Disorders — NEJM Evidence, 2024 doi
- Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity — The New England Journal of Medicine, 2024 doi
- Exploring the Link Between Vitamin D Deficiency and Obstructive Sleep Apnea: A Comprehensive Review — Journal of Sleep Research, 2024 doi
- Male Hypogonadism: Pathogenesis, Diagnosis, and Management — Diabetes & Endocrinology, 2024 doi
- Dietary Fat Quality and Serum Androgen Concentrations in Middle-Aged Men — European Journal of Clinical Nutrition, 2024 doi
- Do "Testosterone Boosters" Really Increase Serum Total Testosterone? A Systematic Review — International Journal of Impotence Research, 2024 doi
- Testosterone Treatment and Fractures in Men with Hypogonadism — The New England Journal of Medicine, 2024 doi
- Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men With Hypogonadism — The Journal of Clinical Endocrinology and Metabolism, 2024 doi
- Depressive Syndromes in Men With Hypogonadism in the TRAVERSE Trial: Response to Testosterone-Replacement Therapy — The Journal of Clinical Endocrinology and Metabolism, 2024 doi
- Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men : Individual Participant Data Meta-Analyses — Annals of Internal Medicine, 2024 doi
- Cushing Syndrome: A Review — JAMA, 2023 doi
- Diagnosis and Management of Pituitary Adenomas: A Review — JAMA, 2023 doi
- Correlation Between Serum Zinc and Testosterone: A Systematic Review — Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 2023 doi
- The Effects of Sleep Deprivation and Obstructive Sleep Apnea Syndrome on Male Reproductive Function: A Multi-Arm Randomised Trial — Journal of Sleep Research, 2023 doi
- Long-Term Green-Mediterranean Diet May Favor Fasting Morning Cortisol Stress Hormone; The DIRECT-PLUS Clinical Trial — Frontiers in Endocrinology, 2023 doi
- Obstructive Sleep Apnea and Serum Total Testosterone: A System Review and Meta-Analysis — Sleep & Breathing = Schlaf & Atmung, 2023 doi
- The Role of Magnesium in Sleep Health: A Systematic Review of Available Literature — Biological Trace Element Research, 2023 doi
- Sustained Improvements in the Cardiometabolic Profile of Patients With Obstructive Sleep Apnea After a Weight-Loss Mediterranean Diet/Lifestyle Intervention: 12-Month Follow-Up (6 Months Post-Intervention) of the "MIMOSA" Randomized Clinical Trial — Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 2023 doi
- Nutritional Modulation of Sleep Latency, Duration, and Efficiency: A Randomized, Repeated-Measures, Double-Blind Deception Study — Medicine and Science in Sports and Exercise, 2023 doi
- Prostate Safety Events During Testosterone Replacement Therapy in Men With Hypogonadism: A Randomized Clinical Trial — JAMA Network Open, 2023 doi
- Cardiovascular Safety of Testosterone-Replacement Therapy — The New England Journal of Medicine, 2023 doi
- Exploring the Efficacy and Safety of a Novel Standardized Ashwagandha (Withania Somnifera) Root Extract (Witholytin®) in Adults Experiencing High Stress and Fatigue in a Randomized, Double-Blind, Placebo-Controlled Trial — Journal of Psychopharmacology (Oxford, England), 2023 doi
- Sleep, testosterone and cortisol balance, and ageing men — Reviews in Endocrine & Metabolic Disorders, 2022 doi
- Aging and Androgens: Physiology and Clinical Implications — Reviews in Endocrine & Metabolic Disorders, 2022 doi
- Modulation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis by Plants and Phytonutrients: A Systematic Review of Human Trials — Nutritional Neuroscience, 2022 doi
- Effects of Resistance Training Intensity on Heart Rate Variability at Rest and in Response to Orthostasis in Middle-Aged and Older Adults — International Journal of Environmental Research and Public Health, 2022 doi
- Effect of an Interdisciplinary Weight Loss and Lifestyle Intervention on Obstructive Sleep Apnea Severity: The INTERAPNEA Randomized Clinical Trial — JAMA Network Open, 2022 doi
- Association of Magnesium Intake With Sleep Duration and Sleep Quality: Findings From the CARDIA Study — Sleep, 2022 doi
- Dose-Response Relationship Between Weight Loss and Improvements in Obstructive Sleep Apnea Severity After a Diet/Lifestyle Interventions: Secondary Analyses of the "MIMOSA" Randomized Clinical Trial — Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine, 2022 doi
- Effects of Exercise Training on Anabolic and Catabolic Hormones with Advanced Age: A Systematic Review — Sports Medicine (Auckland, N.Z.), 2022 doi
- Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review — Clinical Therapeutics, 2022 doi
- Examining the Effects of Calorie Restriction on Testosterone Concentrations in Men: A Systematic Review and Meta-Analysis — Nutrition Reviews, 2022 doi
- Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post‐hoc analysis of a randomised controlled trial — Stress and Health : Journal of the International Society for the Investigation of Stress, 2021 doi
- Effects of Health Behavior Interventions on Psychosocial Outcomes and Cortisol Regulation Among Chronically Stressed Midlife and Older Adults — International Journal of Behavioral Medicine, 2021 doi
- Effect of Partial and Total Sleep Deprivation on Serum Testosterone in Healthy Males: A Systematic Review and Meta-Analysis — Sleep Medicine, 2021 doi
- Consensus on Diagnosis and Management of Cushing's Disease: A Guideline Update — Diabetes & Endocrinology, 2021 doi
- Omega-3 Supplementation and Stress Reactivity of Cellular Aging Biomarkers: An Ancillary Substudy of a Randomized, Controlled Trial in Midlife Adults — Molecular Psychiatry, 2021 doi
- Long‐term magnesium supplementation improves glucocorticoid metabolism: A post‐hoc analysis of an intervention trial — Clinical Endocrinology, 2021 doi
- A Weight-Loss Mediterranean Diet/Lifestyle Intervention Ameliorates Inflammation and Oxidative Stress in Patients With Obstructive Sleep Apnea: Results of the "MIMOSA" Randomized Clinical Trial — European Journal of Nutrition, 2021 doi
- The Effectiveness of a Weight-Loss Mediterranean Diet/Lifestyle Intervention in the Management of Obstructive Sleep Apnea: Results of the "MIMOSA" Randomized Clinical Trial — Clinical Nutrition (Edinburgh, Scotland), 2021 doi
- Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review — Journal of the American College of Cardiology, 2021 doi
- Changes in cortisol levels by continuous positive airway pressure in patients with obstructive sleep apnoea: Meta‐analysis of 637 individuals — Clinical Endocrinology, 2021 doi
- Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association — Circulation, 2021 doi
- Examining the Effects of Herbs on Testosterone Concentrations in Men: A Systematic Review — Advances in Nutrition (Bethesda, Md.), 2021 doi
- Sociodemographic, lifestyle and medical influences on serum testosterone and sex hormone–binding globulin in men from UK Biobank — Clinical Endocrinology, 2021 doi
- Testosterone and Exercise: Effects on Fitness, Body Composition, and Strength in Middle-to-Older Aged Men With Low-Normal Serum Testosterone Levels — Heart and Circulatory Physiology, 2021 doi
- The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: A Systematic Review — Plant Foods for Human Nutrition (Dordrecht, Netherlands), 2020 doi
- Colon-Delivered Short-Chain Fatty Acids Attenuate the Cortisol Response to Psychosocial Stress in Healthy Men: A Randomized, Placebo-Controlled Trial — Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 2020 doi
- Age and Time-of-Day Differences in the Hypothalamo-Pituitary-Testicular, and Adrenal, Response to Total Overnight Sleep Deprivation — Sleep, 2020 doi
- The Association Between Popular Diets and Serum Testosterone Among Men in the United States — The Journal of Urology, 2020 doi
- Glucocorticoids Affect Male Testicular Steroidogenesis — Physiological Research, 2020 doi
- Diagnosis and Management of Obstructive Sleep Apnea: A Review — JAMA, 2020 doi
- Educational, Supportive and Behavioural Interventions to Improve Usage of Continuous Positive Airway Pressure Machines in Adults With Obstructive Sleep Apnoea — The Cochrane Database of Systematic Reviews, 2020 doi
- Influence of Dietary Sources of Melatonin on Sleep Quality: A Review — Journal of Food Science, 2020 doi
- Reviewing the Evidence on Vitamin D Supplementation in the Management of Testosterone Status and Its Effects on Male Reproductive System (Testis and Prostate): Mechanistically Dazzling but Clinically Disappointing — Clinical Therapeutics, 2020 doi
- A Randomized Controlled Pilot Trial of Sleep Health Education on Body Composition Changes Following 10 Weeks' Resistance Exercise — The Journal of Sports Medicine and Physical Fitness, 2020 doi
- Psychotropic Effects of -Theanine and Its Clinical Properties: From the Management of Anxiety and Stress to a Potential Use in Schizophrenia — Pharmacological Research, 2019 doi
- Cognitive Behavioral Therapy, Mindfulness, and Cortisol Habituation: A Randomized Controlled Trial — Psychoneuroendocrinology, 2019 doi
- An Investigation Into the Stress-Relieving and Pharmacological Actions of an Ashwagandha (Withania Somnifera) Extract: A Randomized, Double-Blind, Placebo-Controlled Study — Medicine, 2019 doi
- A Clinical Perspective of Sleep and Andrological Health: Assessment, Treatment Considerations, and Future Research — The Journal of Clinical Endocrinology and Metabolism, 2019 doi
- Positional Therapy for Obstructive Sleep Apnoea — The Cochrane Database of Systematic Reviews, 2019 doi
- Clinical Use of the STOP-BANG Questionnaire to Determine Postoperative Risk in Veterans — The Laryngoscope, 2019 doi
- Obstructive Sleep Apnea in Adults — The New England Journal of Medicine, 2019 doi
- Weight Loss and Lifestyle Interventions for Obstructive Sleep Apnoea in Adults: Systematic Review and Meta-Analysis — Obesity Reviews : An Official Journal of the International Association for the Study of Obesity, 2019 doi
- Effects of CPAP on Testosterone Levels in Patients With Obstructive Sleep Apnea: A Meta-Analysis Study — Frontiers in Endocrinology, 2019 doi
- Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis — The Journal of Clinical Endocrinology and Metabolism, 2019 doi
- Evaluation and Management of Testosterone Deficiency: AUA Guideline — The Journal of Urology, 2018 doi
- Omega-3 Polyunsaturated Fatty Acid Levels and Dysregulations in Biological Stress Systems — Psychoneuroendocrinology, 2018 doi
- Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline — The Journal of Clinical Endocrinology and Metabolism, 2018 doi
- Endurance- And Resistance-Trained Men Exhibit Lower Cardiovascular Responses to Psychosocial Stress Than Untrained Men — Frontiers in Psychology, 2018 doi
- Vitamin D and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis — Sleep Medicine, 2018 doi
- The Role of Weight Management in the Treatment of Adult Obstructive Sleep Apnea — American Journal of Respiratory and Critical Care Medicine, 2018 doi
- Yoga, Mindfulness-Based Stress Reduction and Stress-Related Physiological Measures: A Meta-Analysis — Psychoneuroendocrinology, 2017 doi
- An Update on the Various Practical Applications of the STOP-Bang Questionnaire in Anesthesia, Surgery, and Perioperative Medicine — Current Opinion in Anaesthesiology, 2017 doi
- Diet and Exercise in the Management of Obstructive Sleep Apnoea and Cardiovascular Disease Risk — European Respiratory Review : An Official Journal of the European Respiratory Society, 2017 doi
- Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline — Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine, 2017 doi
- Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone: A Controlled Clinical Trial — JAMA Internal Medicine, 2017 doi
- A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management — The Journal of Clinical Endocrinology and Metabolism, 2017 doi
- Complications of Cushing's Syndrome: State of the Art — Diabetes & Endocrinology, 2016 doi
- Efficacy of Nasal Continuous Positive Airway Pressure on Patients With OSA With Erectile Dysfunction and Low Sex Hormone Levels — Respiratory Medicine, 2016 doi
- Sleep Apnoea and the Hypothalamic-Pituitary-Adrenal Axis in Men and Women: Effects of Continuous Positive Airway Pressure — The European Respiratory Journal, 2016 doi
- STOP-Bang Questionnaire: A Practical Approach to Screen for Obstructive Sleep Apnea — Chest, 2016 doi
- Increased Physical Activity Has a Greater Effect Than Reduced Energy Intake on Lifestyle Modification-Induced Increases in Testosterone — Journal of Clinical Biochemistry and Nutrition, 2016 doi
- Glucocorticoid Regulation of Reproduction — Advances in Experimental Medicine and Biology, 2015 doi
- Metabolic and hormonal effects of ‘catch‐up’ sleep in men with chronic, repetitive, lifestyle‐driven sleep restriction — Clinical Endocrinology, 2015 doi
- The Sleep-Promoting and Hypothermic Effects of Glycine Are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus — Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 2015 doi
- Vitamin D supplementation and testosterone concentrations in male human subjects — Clinical Endocrinology, 2015 doi
- Effects of a 12-Week Endurance Training Program on the Physiological Response to Psychosocial Stress in Men: A Randomized Controlled Trial — Journal of Behavioral Medicine, 2014 doi
- Resistance Training Restores Muscle Sex Steroid Hormone Steroidogenesis in Older Men — FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2014 doi
- A Soy-Based Phosphatidylserine/ Phosphatidic Acid Complex (PAS) Normalizes the Stress Reactivity of Hypothalamus-Pituitary-Adrenal-Axis in Chronically Stressed Male Subjects: A Randomized, Placebo-Controlled Study — Lipids in Health and Disease, 2014 doi
- The role of cherries in exercise and health — Scandinavian Journal of Medicine & Science in Sports, 2014 doi
- Efficacy of Continuous Positive Airway Pressure on Testosterone in Men With Obstructive Sleep Apnea: A Meta-Analysis — PloS One, 2014 doi
- Diagnosis of Obstructive Sleep Apnea in Adults: A Clinical Practice Guideline From theAmerican College of Physicians — Annals of Internal Medicine, 2014 doi
- The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men — International Journal of Endocrinology, 2014 doi
- Age-Associated Changes in Hypothalamic-Pituitary-Testicular Function in Middle-Aged and Older Men Are Modified by Weight Change and Lifestyle Factors: Longitudinal Results From the European Male Ageing Study — European Journal of Endocrinology, 2013 doi
- Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia — Journal of Pineal Research, 2013 doi
- Restoring the Salivary Cortisol Awakening Response Through Nasal Continuous Positive Airway Pressure Therapy in Obstructive Sleep Apnea — Chronobiology International, 2013 doi
- Effect of Tart Cherry Juice (Prunus Cerasus) on Melatonin Levels and Enhanced Sleep Quality — European Journal of Nutrition, 2012 doi
- High STOP-Bang Score Indicates a High Probability of Obstructive Sleep Apnoea — British Journal of Anaesthesia, 2012 doi
- New Therapeutic Strategy for Amino Acid Medicine: Glycine Improves the Quality of Sleep — Journal of Pharmacological Sciences, 2012 doi
- Orexin Neurons Receive Glycinergic Innervations — PloS One, 2011 doi
- Effects of Magnesium Supplementation on Testosterone Levels of Athletes and Sedentary Subjects at Rest and After Exhaustion — Biological Trace Element Research, 2011 doi
- Testosterone Physiology in Resistance Exercise and Training: The Up-Stream Regulatory Elements — Sports Medicine (Auckland, N.Z.), 2010 doi
- Hypothalamic-Pituitary-Adrenal Axis Activation in Obstructive Sleep Apnea: The Effect of Continuous Positive Airway Pressure Therapy — The Journal of Clinical Endocrinology and Metabolism, 2009 doi
- Magnesium Effect on Testosterone-SHBG Association Studied by a Novel Molecular Chromatography Approach — Journal of Pharmaceutical and Biomedical Analysis, 2009 doi
- The Effects of Phosphatidylserine on Endocrine Response to Moderate Intensity Exercise — Journal of the International Society of Sports Nutrition, 2008 doi
- Acute Emotional Stress and Cardiac Arrhythmias — JAMA, 2007 doi
- Cortisol secretary pattern and glucocorticoid feedback sensitivity in women from a Mediterranean area: relationship with anthropometric characteristics, dietary intake and plasma fatty acid profile — Clinical Endocrinology, 2007 doi
- Effects of Phosphatidylserine Supplementation on Exercising Humans — Sports Medicine (Auckland, N.Z.), 2006 doi
- Effects of Soy Lecithin Phosphatidic Acid and Phosphatidylserine Complex (PAS) on the Endocrine and Psychological Responses to Mental Stress — Stress (Amsterdam, Netherlands), 2004 doi
- Effect of Training Status and Exercise Mode on Endogenous Steroid Hormones in Men — : 1985), 2004 doi
- Oral Mg(2+) Supplementation Reverses Age-Related Neuroendocrine and Sleep EEG Changes in Humans — Pharmacopsychiatry, 2002 doi
- Blunting by Chronic Phosphatidylserine Administration of the Stress-Induced Activation of the Hypothalamo-Pituitary-Adrenal Axis in Healthy Men — European Journal of Clinical Pharmacology, 1992 doi
- Neuroendocrine Dysfunction in Sleep Apnea: Reversal by Continuous Positive Airways Pressure Therapy — The Journal of Clinical Endocrinology and Metabolism, 1989 doi
The strength of this evidence varies: some are large reviews and meta-analyses, some are small single studies. The steps in the article are simple, low-risk self-care measures, not treatment, and they may not suit everyone.
This is general information, not a prescription. Tests and treatment are chosen by a doctor.